Senescent cells
Senescent cells no longer actively participate in the cell cycle and no longer fulfill normal cellular functions.
Senescent cells are cells in our body that have entered a state of senescence or standstill. This condition occurs when cells no longer function normally and no longer actively participate in the cell cycle. An interesting feature of senescent cells is their pro-inflammatory secretome.
The pro-inflammatory secretome refers to the substances or molecules released by senescent cells that can promote inflammation in the body. This process is known as the “senescent secretory phenotype”. The secretome released contains various messenger substances, such as cytokines and proteases, which are involved in the regulation of inflammatory reactions.
Senolytic therapy for COPD
A promising breakthrough in the field of COPD treatment has been achieved with the use of senolytics, which specifically eliminate senescent cells. The VITUS Private Clinic is working on making this innovative therapy available to patients.
The potential benefits of senolytics for neurodegenerative diseases
Senolytics such as Dasatinib and Quercetin could represent a promising approach for treating neurodegenerative diseases. These medications aim to selectively eliminate senescent cells, also known as “zombie cells,” potentially slowing down or even reversing the progression and symptoms of diseases such as Alzheimer’s, Parkinson’s, and other neurodegenerative conditions.
The Potential Benefits of Senolytics for Treating Osteoarthritis
Senolytics like Dasatinib and Quercetin could offer a promising approach to treating osteoarthritis. These medications target senescent cells, also known as “zombie cells,” selectively killing them, potentially slowing down or even reversing the progression and symptoms of osteoarthritis.
The Potential Benefits of Senolytics for Anti-Aging
Senolytics like Dasatinib and Quercetin could not only offer a promising approach to treating osteoarthritis but also have positive effects in the realm of anti-aging. These medications target senescent cells, also known as “zombie cells,” selectively eliminating them, potentially slowing down the progression and symptoms of osteoarthritis while simultaneously slowing the aging process.
Inflammaging
The effects of senescent cells and their pro-inflammatory secretome on the body are manifold. On the one hand, senescence plays a role in the ageing process and is associated with various age-related diseases. On the other hand, senescent cells can also play a role in inflammatory processes, which in turn are associated with various diseases such as arthritis, cardiovascular diseases and even cancer.
The inflammation caused by senescent cells can lead to an imbalance in the immune system and impair normal tissue function. This in turn could increase susceptibility to certain diseases and affect general health.
Research into senescent cells and their influence on the body is an emerging field in biomedicine. Understanding these processes could potentially help to develop new approaches for the treatment of age-related diseases and the promotion of healthy ageing.
The removal or reduction of senescent cells in the body is an area of active research and there are various approaches being considered. It is important to note that many of these approaches are still in the early stages of research, and their long-term efficacy and safety need to be further investigated. Some of the promising approaches include:
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Senolytics
Senolytics are compounds or drugs that are specifically aimed at eliminating senescent cells. These substances can help to reduce the number of senescent cells in the body. Various senolytic compounds, including the investigated dasatinib and quercetin, show promising results in preclinical studies.
Exercise and sport
Regular physical activity has been associated with the reduction of senescent cells. Exercise can help to slow down the ageing process and improve general well-being.
Calorie reduction
Some studies suggest that calorie reduction or intermittent fasting can have a positive effect on senescence. These nutritional approaches could stimulate the body to regenerate better and eliminate senescent cells.
Antioxidant
Antioxidants can help to reduce oxidative stress, which is associated with the development of senescent cells. A balanced diet with plenty of antioxidant-rich foods, such as fruit and vegetables, can therefore be beneficial.
Medication approaches
In addition to senolytics, other drugs that could potentially influence senescence are also being investigated. These drugs could slow down or even reverse senescence.
The combination of dasatinib and quercetin is a promising strategy in the field of senolytics, which aims to eliminate senescent cells. Senolytics are substances that are specifically aimed at eliminating these ageing cells that no longer function normally. Here is some information on the use of dasatinib and quercetin:
Dasatinib
Our infusion program is designed to meet the unique needs of each individual. Through a thorough analysis of your health situation, we create a customized infusion protocol that is tailored to your specific requirements.
Studies: Early preclinical studies showed that dasatinib can reduce the number of senescent cells in tissues.
Quercetin
Natural flavonoid: Quercetin is a naturally occurring flavonoid found in many types of fruit and vegetables. It has antioxidant properties and is valued for its potential anti-inflammatory effects.
Senolytic properties: Quercetin alone has senolytic properties, but may show synergistic effects in combination with dasatinib.
Application
Combination therapy
Dasatinib and quercetin are often used in combination therapy. The idea is that the two substances in combination can eliminate senescent cells more effectively.
Dosing and monitoring: Accurate dosing and administration should be under the direction of a qualified physician or healthcare provider.
It is important to emphasize that these approaches are still in the research phase and are not considered standard treatment. These substances should only be used outside of clinical trials under medical supervision.